Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations
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چکیده
منابع مشابه
PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients.
PURPOSE To characterize pregnane X receptor (PXR) polymorphic variants in healthy Asian populations [Chinese, Malay and Indian (n=100 each)], and to investigate the association between PXR haplotypes and hepatic mRNA expression of PXR and its downstream target genes, CYP3A4 and ABCB1, as well as their influence on the clearance of doxorubicin in Asian breast cancer patients. EXPERIMENTAL DESI...
متن کاملFrequencies of single-nucleotide polymorphisms and haplotypes of the SLCO1B1 gene in selected populations of the western balkans
As a membrane influx transporter, organic anion-transporting polypeptide 1B1 (OATP1B1) regulates the cellular uptake of a number of endogenous compounds and drugs. The aim of this study was to characterize the diversity of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encoding this transporter in two ethnic groups populating the Western Balkans. The distribution ...
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این تحقیق کوشیده است با انتخاب پنج رمان از میان آثار برگزیده، «چارلز دیکنز»، «جورج الیوت» و «توماس هاردی » و با رویکردی تطبیقی به بررسی درونمایه ی «ازدواج» در آثار این سه رمان نویس بزرگ دوره ی ویکتوریا بپردازد. فرضیه ی اولیه ی تحقیق این بوده است که چارلز دیکنز (1870- 1812) با زبانی شوخ و گزنده، جورج الیوت(1880- 1819) با نگاهی آموزشی–اندرزگونه و توماس هاردی(1928- 1840) با رویکردی تلخ وانتقادی به...
Knops blood group haplotypes among distinct Brazilian populations.
BACKGROUND The Knops blood group system consists of antigens encoded by exon 29 of complement receptor 1 (CR1) gene. To better elucidate the complexity of Knops group system, the frequency of six single-nucleotide polymorphisms (SNPs) in three Brazilian populations is determined. STUDY DESIGN AND METHODS A total of 118 individuals descendant from Europe, Asia, and Africa were studied. The gen...
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Glucuronidation is a critical and elimination process in the detoxification of many different exogenous and endogenous compounds (Radominska-Pandya et al., 1999; Tukey & Strassburg, 2001). Glucuronides account for ~35% of all phase II drug metabolites (Evans & Relling, 1999), including therapeutic drugs such as SN-38, which is the active antitumor metabolite of the prodrug irinotecan, as well a...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2007
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-007-0336-y